Article
Models of the cardiac L-type calcium current: A quantitative review.
WIREs mechanisms of disease - 1 Jan 2023
Agrawal Aditi, Wang Ken, Polonchuk Liudmila, Cooper Jonathan, Hendrix Maurice, Gavaghan David J, Mirams Gary R, Clerx Michael
Abstract excerpt
The L-type calcium current ( I CaL ) plays a critical role in cardiac electrophysiology, and models of I CaL are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modeling I CaL have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data-driven critical comparison...
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