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Article

Ageing-dependent remodelling of ion channel and Ca<sup>2+</sup>clock genes underlying sino-atrial node pacemaking

4 Jul 2011

Abstract excerpt

The function of the sino-atrial node (SAN), the pacemaker of the heart, is known to decline with age, resulting in pacemaker disease in the elderly. The aim of the study was to investigate the effects of ageing on the SAN by characterizing electrophysiological changes and determining whether changes in gene expression are involved. In young and old rats, SAN function was characterized in the anaesthetized animal,...

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Share to Cardiac electrophysiology and arrhythmias
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Identifiers

PMID: 21724736
DOI: 10.1113/expphysiol.2011.057752

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