Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2011

Kharche Sanjay, Yu Jian, Lei Ming, Zhang Henggui

Abstract excerpt

Genetically modified mice are popular experimental models for studying the molecular bases and mechanisms of cardiac arrhythmia. A postgenome challenge is to classify the functional roles of genes in cardiac function. To unveil the functional role of various genetic isoforms of ion channels in generating cardiac pacemaking action potentials (APs), a mathematical model for spontaneous APs of mouse sinoatrial node...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Clocks

Share to Calcium Signaling

Share to Ion Transport

Share to Models, Cardiovascular

Share to Potassium

Share to Sodium

Source

Open in PubMed Open full text

Identifiers

PMID: 21724866
DOI: 10.1152/ajpheart.00143.2010
PMCID: PMC3191499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.PMID 21724866Read ↗

A novel ionic model for matured and paced atrial–like hiPSC–CMs integrating <i>I</i> <sub> <i>Kur</i> </sub> and <i>I</i> <sub> <i>KCa</i> </sub> currentsSemantic proximity Read ↗

Models of the cardiac L-type calcium current: A quantitative review.Semantic proximity Read ↗

Computational analysis of the human sinus node action potential: model development and effects of mutations.Semantic proximity Read ↗

Fibrosis, Electrics and GeneticsSemantic proximity Read ↗

Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor StimulationSemantic proximity Read ↗

From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study.Semantic proximity Read ↗

Reciprocal interaction between I <sub>K1</sub> and I <sub>f</sub> in biological pacemakers: A simulation studySemantic proximity Read ↗

Computational Model for Simulating Drug-Induced Arrhythmia Sensitivity of Human iPSC-derived CardiomyocytesSemantic proximity Read ↗

Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue ModelsSemantic proximity Read ↗

A model of cellular cardiac-neural coupling that captures the sympathetic control of sinoatrial node excitability in normotensive and hypertensive rats.Semantic proximity Read ↗

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.Semantic proximity Read ↗

From genome to physiome: integrative models of cardiac excitation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.