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Article

Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2024

Pizzo Emanuele, Cervantes Daniel O, Ketkar Harshada, Ripa Valentina, Nassal Drew M, Buck Benjamin, Parambath Sreema P, Di Stefano Valeria, Singh Kanwardeep, Thompson Carl I, Mohler Peter J, Hund Thomas J, Jacobson Jason T, Jain Sudhir, Rota Marcello

Abstract excerpt

Diastolic dysfunction and delayed ventricular repolarization are typically observed in the elderly, but whether these defects are intimately associated with the progressive manifestation of the aging myopathy remains to be determined. In this regard, aging in experimental animals is coupled with increased late Na+ current (INa,L) in cardiomyocytes, raising the possibility that INa,L conditions the modality of...

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PMID: 38639742
DOI: 10.1152/ajpheart.00325.2023

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