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Article

Delayed pharyngeal repolarization promotes abnormal calcium buildup in aging muscle.

Biochemical and biophysical research communications - 12 Apr 2013

Swiatkowski Przemyslaw, Sesti Federico

Abstract excerpt

In the pharynx of Caenorhabditis elegans, the accessory subunit MPS-4, homolog to human KCNE1, forms a complex with K(+) channel EXP-2 that terminates the action potential. An aspartate residue critical for KCNE1 function, asp76, is conserved in MPS-4 (asp74). Here, we studied the effects of D74N-MPS-4 on the aging pharynx. Electrophysiological studies showed that D74N delays pharyngeal repolarization. Pharynxes...

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PMID: 23510998
DOI: 10.1016/j.bbrc.2013.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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