Article

BIN1 knockdown rescues systolic dysfunction in the aging heart

2022-08-25

Abstract excerpt

Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenated cardiac function and substantially reversed the aging phenotype. Our data indicate that age-associated overexpression of BIN1 occurs alongside dysregulated endosomal recycling and disrupted trafficking of cardi...

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Identifiers and source

Literature Corpus work: 8426d021-089b-5df6-b288-652b547e0463
DOI: 10.1101/2022.08.23.504979

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