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Article

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2018

Zill Oliver A, Banks Kimberly C, Fairclough Stephen R, Mortimer Stefanie A, Vowles James V, Mokhtari Reza, Gandara David R, Mack Philip C, Odegaard Justin I, Nagy Rebecca J, Baca Arthur M, Eltoukhy Helmy, Chudova Darya I, Lanman Richard B, Talasaz AmirAli

Abstract excerpt

Purpose: Cell-free DNA (cfDNA) sequencing provides a noninvasive method for obtaining actionable genomic information to guide personalized cancer treatment, but the presence of multiple alterations in circulation related to treatment and tumor heterogeneity complicate the interpretation of the observed variants.Experimental Design: We describe the somatic mutation landscape of 70 cancer genes from cfDNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29776953
DOI: 10.1158/1078-0432.CCR-17-3837

Genes

EGFR
ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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