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Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation

5 Mar 2024

Abstract excerpt

Synucleinopathies refer to a group of disorders characterized by SNCA/α-synuclein (α-Syn)-containing cytoplasmic inclusions and neuronal cell loss in the nervous system including the cortex, a common feature being cognitive impairment. Still, the molecular pathogenesis of cognitive decline remains poorly understood, hampering the development of effective treatments. Here, we generated induced pluripotent stem...

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PMID: 38444039
DOI: 10.1186/s13041-024-01086-6

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