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Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson’s Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpression

2025-07-23

Abstract excerpt

Cognitive impairment is the most common and detrimental, but understudied non-motor symptom of Parkinson’s disease (PD). Neuropathologically, it is associated with alpha-synuclein (αSyn) misfolding and synapse loss in hippocampus and prefrontal cortex, leading to cognition loss and ultimately dementia. The molecular underpinnings of PD-associated cognitive dysfunction are unknown. In the present study, longitudina...

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Literature Corpus work
65348148-b400-5f74-8133-1d82441ebe63
DOI
10.1101/2025.07.18.665564
Open publication

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Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson’s Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpressionDOI 10.1101/2025.07.18.665564
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