Article

AFM kymographs can provide robust conformational transition detection for pharmaceutically relevant membrane proteins in lipid bilayers

2023-04-13

Abstract excerpt

Membrane proteins play critical roles in disease and in the disposition of many pharmaceuticals. A prime example is P-glycoprotein (Pgp) which moves a diverse range of drugs across membranes and out of the cell before a therapeutic payload can be delivered. Conventional structural biology methods have provided a valuable framework for comprehending the complex conformational changes underlying Pgp function, which...

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Identifiers and source

Literature Corpus work: 67f13a9a-93ae-5216-b913-1e9e5d0fb505
DOI: 10.21203/rs.3.rs-2782124/v1

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