Article
Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy.
Nature nanotechnology - 1 Feb 2021
Kodera Noriyuki, Noshiro Daisuke, Dora Sujit K, Mori Tetsuya, Habchi Johnny, Blocquel David, Gruet Antoine, Dosnon Marion, Salladini Edoardo, Bignon Christophe, Fujioka Yuko, Oda Takashi, Noda Nobuo N, Sato Mamoru, Lotti Marina, Mizuguchi Mineyuki, Longhi Sonia, Ando Toshio
Abstract excerpt
Intrinsically disordered proteins (IDPs) are ubiquitous proteins that are disordered entirely or partly and play important roles in diverse biological phenomena. Their structure dynamically samples a multitude of conformational states, thus rendering their structural analysis very difficult. Here we explore the potential of high-speed atomic force microscopy (HS-AFM) for characterizing the structure and dynamics...
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