Article

Correlating membrane-protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single-molecule FRET

2025-06-05

Abstract excerpt

We present a strategy that deploys structural bioinformatics, molecular simulation, and single-molecule FRET microscopy for observing the ligand-dependent conformational dynamics of integral membrane proteins in situ. We focus on representative members of the small monotopic phosphoglycosyl transferase (SmPGT) superfamily, which catalyze transfer of a phosphosugar from a soluble nucleotide-sugar donor to a membra...

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Literature Corpus work: be5b5d86-aaaa-5d14-890f-f5e70e1ab156
DOI: 10.1101/2025.06.05.658054

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