Article

Phosphate Ions Alter the Binding of Daptomycin to Living Cell Membranes

2020-10-01

Abstract excerpt

Advancements in antibiotic drug design are often hindered by missing information in how these small molecules interact with living cells. The antibiotic, daptomycin, has found clinical success, and emerging resistance, but a comprehensive picture of its mechanism of action has remained elusive. Using the surface-specific spectroscopy, second harmonic generation, we are able to quantitatively assess the binding of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f49a3987-01a5-5cab-b6bf-620a808caf52
DOI: 10.26434/chemrxiv.13031144.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phosphate Ions Alter the Binding of Daptomycin to Living Cell MembranesDOI 10.26434/chemrxiv.13031144.v1Read

Phosphate Ions Alter the Binding of Daptomycin to Living Bacterial Cell SurfacesSemantic proximity Read

Virulence Induction in Pseudomonas aeruginosa under Inorganic Phosphate Limitation: a Proteomics PerspectiveSemantic proximity Read

Inorganic Polyphosphate: Essential for Growth and SurvivalSemantic proximity Read

Stable and Reversible Functionalization of the Native Phosphate Groups on Live CellsSemantic proximity Read

A purpurin-peptide derivative for selective killing of Gram-positive bacteria via insertion into cell membraneSemantic proximity Read

Stable and Reversible Functionalization of the Native Phosphate Groups on Live CellsSemantic proximity Read

Microspectrometric insights on the uptake of antibiotics at the single bacterial cell levelSemantic proximity Read

The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interfaceSemantic proximity Read

Inhibition of Multiple Staphylococcal Growth States by a Small Molecule that Disrupts Membrane Fluidity and VoltageSemantic proximity Read

Dipicolylamine‐Zn Induced Targeting and Photo‐Eliminating of Pseudomonas aeruginosa and Drug‐Resistance Gram‐Positive BacteriaSemantic proximity Read

Rapid Fluorescence Assay for Polyphosphate in Yeast Extracts Using JC‐D7Semantic proximity Read

Salt-bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT.Semantic proximity Read