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Article

Direct visualization of saposin remodelling of lipid bilayers.

Journal of molecular biology - 6 Oct 2006

Alattia Jean-René, Shaw James E, Yip Christopher M, Privé Gilbert G

Abstract excerpt

Saposins A, B, C and D are soluble, non-enzymatic proteins that interact with lysosomal membranes to activate the breakdown and transfer of glycosphingolipids. The mechanisms of hydrolase activation and lipid transfer by saposins remain unknown. We have used in situ atomic force microscopy (AFM) with simultaneous confocal fluorescence microscopy to investigate the interactions of saposins with lipid membranes....

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Source

Identifiers

PMID: 16949605
DOI: 10.1016/j.jmb.2006.08.009

Genes

AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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