Article

Astrocytic Regulation of Basal Ganglia Dopamine/D2-Dependent Behaviors

2021-05-11

Abstract excerpt

Astrocytic involvement in dopamine dynamics related to motivational and sensorimotor gating abilities is unknown. We found that dysbindin-1 (Dys1) hypofunction increases the activity of astrocytes, which express only the isoform Dys1A that is reduced in the caudate of patients with schizophrenia. Astrocytic Dys1A disruption resulted in avolition and sensorimotor gating deficits, increased astrocytic dopamine D2 re...

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Literature Corpus work: 67de0e8f-edbe-5ad6-b7bf-c250c94fce90
DOI: 10.1101/2021.05.11.443394

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