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Article

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors.

Nature neuroscience - 1 Nov 2012

Quintana Albert, Sanz Elisenda, Wang Wengang, Storey Granville P, Güler Ali D, Wanat Matthew J, Roller Bryan A, La Torre Anna, Amieux Paul S, McKnight G Stanley, Bamford Nigel S, Palmiter Richard D

Abstract excerpt

The striatum regulates motor control, reward and learning. Abnormal function of striatal GABAergic medium spiny neurons (MSNs) is believed to contribute to the deficits in these processes that are observed in many neuropsychiatric diseases. The orphan G protein-coupled receptor GPR88 is robustly expressed in MSNs and is regulated by neuropharmacological drugs, but its contribution to MSN physiology and behavior...

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Identifiers

PMID: 23064379
DOI: 10.1038/nn.3239
PMCID: PMC3483418

Genes

GPR88
MSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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