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Article

Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry.

Neuron - 8 Jan 2014

Cazorla Maxime, de Carvalho Fernanda Delmondes, Chohan Muhammad O, Shegda Mariya, Chuhma Nao, Rayport Stephen, Ahmari Susanne E, Moore Holly, Kellendonk Christoph

Abstract excerpt

Structural plasticity in the adult brain is essential for adaptive behavior. We have found a remarkable anatomical plasticity in the basal ganglia of adult mice that is regulated by dopamine D2 receptors (D2Rs). By modulating neuronal excitability, striatal D2Rs bidirectionally control the density of direct pathway collaterals in the globus pallidus that bridge the direct pathway with the functionally opposing...

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Source

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Identifiers

PMID: 24411738
DOI: 10.1016/j.neuron.2013.10.041
PMCID: PMC3899717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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