Article
DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias.
Genes, brain, and behavior - 1 Jul 2010
Fallgatter A J, Ehlis A-C, Herrmann M J, Hohoff C, Reif A, Freitag C M, Deckert J
Abstract excerpt
Dysbindin (DTNBP1) is a recently characterized protein that seems to be involved in the modulation of glutamatergic neurotransmission in the human brain, thereby influencing prefrontal cortex function and associated cognitive processes. While association, neuroanatomical and cellular studies indicate that DTNBP1 might be one of several susceptibility genes for schizophrenia, the effect of dysbindin on prefrontal...
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