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Article

Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

5 Apr 2007

Abstract excerpt

Mutations in the gene encoding alpha-synuclein (asyn) causes autosomal-dominant, in the parkin gene autosomal-recessive forms of Parkinson's disease (PD). The pathophysiology of PD is poorly understood, even though published evidence suggests a role for mitochondria in the pathogenesis. To gain insight into the influence of asyn and parkin on mitochondrial integrity and function, we have generated several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17412759
DOI: 10.1093/hmg/ddm083

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