Article

Mitochondrial protein import stress augments α-synuclein aggregation and neurodegeneration independent of bioenergetics

2022-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Several genetic and environmental risk factors for Parkinson’s disease have been identified that converge on mitochondria as central elements in the disease process. However, the mechanisms by which mitochondrial dysfunction contributes to neurodegeneration remain incompletely understood. Non-bioenergetic pathways of the mitochondria are increasingly appreciated, but confounding bioenergetic def...

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Literature Corpus work: 25871e4a-5f3e-5b1c-b569-60dc5796ab1d
DOI: 10.1101/2022.09.20.508793

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