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α-Synuclein pathology and mitochondrial dysfunction: Toxic partners in Parkinson's disease

29 Mar 2025

Abstract excerpt

Two major neuropathological features of Parkinson's disease (PD) are α-synuclein Lewy pathology and mitochondrial dysfunction. Although both α-synuclein pathology and mitochondrial dysfunction may independently contribute to PD pathogenesis, the interaction between these two factors is not yet fully understood. In this review, we discuss the physiological functions of α-synuclein and mitochondrial homeostasis in...

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PMID: 40157617
DOI: 10.1016/j.nbd.2025.106889

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