Article

The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons

2025-06-17

Abstract excerpt

Mitochondrial dysfunction and oxidative stress are central to Parkinson’s disease (PD) pathogenesis, particularly affecting substantia nigra pars compacta (SNc) dopamine (DA) neurons. Here, we investigate how the R1441G mutation in leucine-rich repeat kinase 2 (LRRK2), a key genetic contributor to familial and sporadic PD, impacts mitochondrial function in midbrain DA neurons. Using a BAC transgenic mouse model ov...

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Literature Corpus work: c030c875-103c-5efd-a334-a2798420fe90
DOI: 10.1101/2025.06.16.660029

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