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Article

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.

Molecular neurobiology - 1 Nov 2024

Hui Sarah, George Jimmy, Kapadia Minesh, Chau Hien, Bariring Zahn, Earnshaw Rebecca, Shafiq Kashfia, Kalia Lorraine V, Kalia Suneil K

Abstract excerpt

Parkinson's disease (PD) is a progressive neurogenerative movement disorder characterized by dopaminergic cell death within the substantia nigra pars compacta (SNpc) due to the aggregation-prone protein α-synuclein. Accumulation of α-synuclein is implicated in mitochondrial dysfunction and disruption of the autophagic turnover of mitochondria, or mitophagy, which is an essential quality control mechanism proposed...

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Identifiers

PMID: 38581539
DOI: 10.1007/s12035-024-04131-6
PMCID: PMC11496319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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