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Topoisomerase-Mediated DNA Damage in Neurological Disorders

25 Nov 2021

Abstract excerpt

The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant to the development of neuronal dysfunction are poorly understood. The identification of primarily neurological abnormalities in patients with mutations in TDP1 and...

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Identifiers

PMID: 34899270
DOI: 10.3389/fnagi.2021.751742

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