Article

Improving cross-ancestry generalizability of genetic risk prediction for short stature using a meta-polygenic risk score

2025-12-18

Abstract excerpt

<h4>Background</h4> Short stature (SS) is associated with adverse clinical, psychosocial, and economic outcomes, and early identification of at-risk individuals may enable timely evaluation and intervention. Polygenic risk scores (PRS) for height offer a promising strategy for SS risk stratification. However, substantial ancestry-related differences in PRS distributions and predictive performance limit equitable...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67926a20-753c-5bda-b46e-4fb5ff07ed6f
DOI: 10.64898/2025.12.16.25342408

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improving cross-ancestry generalizability of genetic risk prediction for short stature using a meta-polygenic risk scoreDOI 10.64898/2025.12.16.25342408Read

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short statureSemantic proximity Read

A Polygenic Risk Score to Predict Future Adult Short Stature Among ChildrenSemantic proximity Read

Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.Semantic proximity Read

Genetic Architecture Associated With Familial Short Stature.Semantic proximity Read

Analysis of Polygenic Score Usage and Performance in Diverse Human PopulationsSemantic proximity Read

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Semantic proximity Read

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature.Semantic proximity Read

Polygenic scores for height in admixed populationsSemantic proximity Read

Polygenic Scores for Height in Admixed Populations.Semantic proximity Read

Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study.Semantic proximity Read

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsSemantic proximity Read

Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index.Semantic proximity Read