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A Polygenic Risk Score to Predict Future Adult Short Stature Among Children

31 Mar 2021

Abstract excerpt

CONTEXT: Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height. OBJECTIVE: To develop a polygenic risk score for adult height and evaluate its clinical utility. DESIGN: A polygenic risk score was constructed based on meta-analysis of genomewide association studies and evaluated on the Avon Longitudinal Study of Parents and Children (ALSPAC)...

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PMID: 33788949
DOI: 10.1210/clinem/dgab215

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