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Article

Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.

HGG advances - 9 Jul 2026

Wang Xin, Sofer Tamar, Frei Oleksandr, Kaplan Robert, Perreira Krista M, Franceschini Nora, Parada Humberto, Zhou Laura, Andreassen Ole A, Gonzalez Hector, Dale Anders M, Broce Iris J

Abstract excerpt

Polygenic scores (PGSs) offer moderate to high prediction accuracy for complex traits, but most are developed in European ancestry cohorts, reducing their performance in populations of other ancestries. This study aimed to improve standing height prediction, a heritable and ancestry-influenced trait, in an admixed Latino cohort, the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), by modeling ancestry...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41904631
DOI: 10.1016/j.xhgg.2026.100597
PMCID: PMC13157043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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