Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature.

Genome medicine - 19 Mar 2025

Shelley John P, Shi Mingjian, Peterson Josh F, Van Driest Sara L, Simmons Jill H, Mosley Jonathan D

Abstract excerpt

BACKGROUND: A subset of children with short stature do not have an identified clinical explanation after extensive diagnostic evaluation. We hypothesized that a polygenic score for height (PGSheight) could identify children with non-familial idiopathic short stature (ISS-NF) who carry a polygenic predisposition to shorter height that is not accounted for by existing measures. METHODS: We studied 534 pediatric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Body Height

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Dwarfism

Share to Genetic Predisposition to Disease

Share to Growth Disorders

Share to Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 40108664
DOI: 10.1186/s13073-025-01455-3
PMCID: PMC11924680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature.PMID 40108664Read ↗

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short statureSemantic proximity Read ↗

A Polygenic Risk Score to Predict Future Adult Short Stature Among ChildrenSemantic proximity Read ↗

Genetic Architecture Associated With Familial Short Stature.Semantic proximity Read ↗

A genetic approach to evaluation of short stature of undetermined cause.Semantic proximity Read ↗

Idiopathic Short Stature: What to Expect from Genomic InvestigationsSemantic proximity Read ↗

Towards identification of molecular mechanisms of short statureSemantic proximity Read ↗

Using height association studies to gain insights into human idiopathic short and syndromic stature phenotypes.Semantic proximity Read ↗

Improving cross-ancestry generalizability of genetic risk prediction for short stature using a meta-polygenic risk scoreSemantic proximity Read ↗

Monogenic causes of familial short stature.Semantic proximity Read ↗

Height matters-from monogenic disorders to normal variation.Semantic proximity Read ↗

Genetic causes of isolated short statureSemantic proximity Read ↗

Influence of polygenic risk on height and BMI in adults with a 22q11.2 microdeletionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.