Article

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature

2024-10-14

Abstract excerpt

<title>Abstract</title> <p>Background A subset of children with short stature do not have an identified clinical explanation and are assigned a diagnosis of idiopathic short stature (ISS). We hypothesized that a polygenic score for height (PGS<sub>height</sub>) could identify children with ISS who have an unrecognized heritable predisposition to shorter height. Methods We examined 534 pediatric participants in...

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Literature Corpus work: 5669ccfa-d3ad-5488-88b5-74409fe5b8cd
DOI: 10.21203/rs.3.rs-4921143/v1

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