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Role of IgG4 Antibodies in Human Health and Disease

25 Apr 2025

Abstract excerpt

Immunoglobulin G4 (IgG4), a unique subclass of IgG antibodies, plays diverse roles in human health and disease. Its distinct features, such as Fab-arm exchange and specific mutations, confer reduced effector functions compared to other IgG subclasses. In health, IgG4 responses contribute to immune tolerance, particularly in the context of allergen-specific immunotherapy (AIT), where they can mediate tolerance to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40358163
DOI: 10.3390/cells14090639

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