Article

Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development

2023-06-30

Abstract excerpt

A subset of autoimmune diseases is characterized by predominant pathogenic IgG4 autoantibodies (IgG4-AIDs). Why IgG4 predominates in these disorders is unknown. We hypothesized that dysregulated B cell maturation or aberrant class switching causes overrepresentation of IgG4 + B cells and plasma cells. Therefore, we compared the B cell compartment of patients with muscle-specific kinase (MuSK) myasthenia gravis (M...

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Literature Corpus work: b0e841b1-2cdb-57c7-b50a-a9499b9d2743
DOI: 10.1101/2023.06.30.546522

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