Back to search

Article

Development and validation of highly selective monoclonal antibodies for the detection of huntingtin neoepitopes

2026-08-26

Abstract excerpt

Huntington's disease is caused by a CAG repeat tract expansion in the huntingtin gene, resulting in production of pathogenic N-terminal huntingtin protein fragments associated with disease pathology. Despite their central role, detection of these fragments has relied on a limited antibody repertoire with reproducibility concerns. Here, we describe the generation and characterization of recombinant rabbit monoclona...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5be667df-ea53-56b9-bf31-67d73d29770a
DOI
10.64898/2026.08.21.746138
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Development and validation of highly selective monoclonal antibodies for the detection of huntingtin neoepitopesDOI 10.64898/2026.08.21.746138
Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington’s diseaseSemantic proximity
Novel monoclonal antibodies against the C-terminal HEAT domain of HuntingtinSemantic proximity
Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human AntibodiesSemantic proximity
From rabbit antibody repertoires to rabbit monoclonal antibodiesSemantic proximity
Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developabilitySemantic proximity
Validation of Tau Antibodies for Use in Western Blotting and ImmunohistochemistrySemantic proximity
Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targetsSemantic proximity
Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platformsSemantic proximity
When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regionsSemantic proximity
A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescenceSemantic proximity
Referencing cross-reactivity of detection antibodies for protein array experimentsSemantic proximity
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistrySemantic proximity
Select a neighboring publication to make it the new centre.