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Article

Epitope mapping of monoclonal antibody 4C8 recognizing the protein huntingtin.

Hybridoma (2005) - 1 Oct 2005

Cong Shu-Yan, Pepers Barry A, Roos Raymund A C, Van Ommen Gert-Jan B, Dorsman Josephine C

Abstract excerpt

Huntington's disease is a dominantly inherited, devastating neurodegenerative disorder, caused by a polyglutamine expansion (>37) in the N-terminal region of huntingtin, a protein of unknown function. In patients and normal individuals, N-terminal fragments of huntingtin are found, and the N-terminal fragments of mutant huntingtin are cytotoxic. The functions of wild-type huntingtin and the mechanisms underlying...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16225422
DOI: 10.1089/hyb.2005.24.231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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