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Article

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.

The Journal of biological chemistry - 7 Aug 2009

Legleiter Justin, Lotz Gregor P, Miller Jason, Ko Jan, Ng Cheping, Williams Geneva L, Finkbeiner Steve, Patterson Paul H, Muchowski Paul J

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine (polyQ) domain in the N-terminal region of huntingtin (htt). PolyQ expansion above 35-40 results in disease associated with htt aggregation into inclusion bodies. It has been hypothesized that expanded polyQ domains adopt multiple potentially toxic conformations that belong to different aggregation pathways. Here, we...

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Identifiers

PMID: 19491400
DOI: 10.1074/jbc.M109.016923
PMCID: PMC2755888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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