Time-resolved assessment of single-cell protein secretion by sequencing

Abstract excerpt

<h4>SUMMARY</h4> Secreted proteins play critical roles in cellular communication and functional orchestration. Methods enabling concurrent measurement of cellular protein secretion, phenotypes and transcriptomes are still unavailable. Here, we describe time-resolved assessment of protein secretion from single cells by sequencing (TRAPS-seq). Released proteins are trapped onto cell surface via affinity matrices, a...

Topics

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• Antibody-Producing Cells
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• NF-kappa B
• RNA
• Single-Cell Gene Expression Analysis
• TOR Serine-Threonine Kinases

Identifiers and source

Literature Corpus work

672538b6-b05b-5b67-8ea0-87023086a1ad

DOI

10.1101/2021.12.19.473400