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Article

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells.

Nature medicine - 1 Jun 2011

Ma Chao, Fan Rong, Ahmad Habib, Shi Qihui, Comin-Anduix Begonya, Chodon Thinle, Koya Richard C, Liu Chao-Chao, Kwong Gabriel A, Radu Caius G, Ribas Antoni, Heath James R

Abstract excerpt

Cellular immunity has an inherent high level of functional heterogeneity. Capturing the full spectrum of these functions requires analysis of large numbers of effector molecules from single cells. We report a microfluidic platform designed for highly multiplexed (more than ten proteins), reliable, sample-efficient (∼1 × 10(4) cells) and quantitative measurements of secreted proteins from single cells. We...

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Identifiers

PMID: 21602800
DOI: 10.1038/nm.2375
PMCID: PMC3681612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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