Article

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

2019-09-04

Abstract excerpt

Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. We used quantitative proteomics, bulk RNA-seq and single-cell RNA-seq of over 40,000 human naïve and memory CD4+ T cells to generate a detailed map of cytokine-regulated gene expression programs. We demonstrated that cytokine r...

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Literature Corpus work: bc217d1e-cfb2-576e-9bac-0903838cbb2d
DOI: 10.1101/753731

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