Article

Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class I and II epitopes

2021-05-02

Abstract excerpt

Cytolytic T cell responses are predicted to be biased towards membrane proteins. The peptide-binding grooves of most haplotypes of histocompatibility complex class I (MHC-I) are relatively hydrophobic, therefore peptide fragments derived from human transmembrane helices (TMHs) are predicted to be presented more often as would be expected based on their abundance in the proteome. However, the physiological reason o...

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Literature Corpus work: 671a307f-58cb-5560-b440-1216c598188f
DOI: 10.1101/2021.05.02.441235

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