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Article

Human self-protein CD8+ T-cell epitopes are both positively and negatively selected.

European journal of immunology - 1 Apr 2009

Almani Michal, Raffaeli Shai, Vider-Shalit Tal, Tsaban Lea, Fishbain Vered, Louzoun Yoram

Abstract excerpt

The cellular immune system recognizes self-epitopes in the context of MHC-I molecules. The immunological general view presumes that these self-epitopes are just a background, both positively and negatively selecting T cells. We here estimate the number of epitopes in each human protein for many frequent HLA alleles, and a score representing over or under presentation of epitopes on these proteins. We further show...

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Share to Alleles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19291702
DOI: 10.1002/eji.200838353
PMCID: PMC2730470

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AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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