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Article

Viruses selectively mutate their CD8+ T-cell epitopes--a large-scale immunomic analysis.

Bioinformatics (Oxford, England) - 15 Jun 2009

Vider-Shalit Tal, Sarid Ronit, Maman Kobi, Tsaban Lea, Levi Ran, Louzoun Yoram

Abstract excerpt

MOTIVATION: Viruses employ various means to evade immune detection. One common evasion strategy is the removal of CD8+cytotoxic T-lymphocyte epitopes. We here use a combination of multiple bioinformatic tools and large amount of genomic data to compute the epitope repertoire presented by over 1300 viruses in many HLA alleles. We define the 'Size of Immune Repertoire score', which represents the ratio between the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19478014
DOI: 10.1093/bioinformatics/btp221
PMCID: PMC2687975

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Source receipt: pubmed, retrieved 7 Sept 2026.

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