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Article

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins.

Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009

Oberai Amit, Joh Nathan H, Pettit Frank K, Bowie James U

Abstract excerpt

The amino acid sequences of transmembrane regions of helical membrane proteins are highly constrained, diverging at slower rates than their extramembrane regions and than water-soluble proteins. Moreover, helical membrane proteins seem to fall into fewer families than water-soluble proteins. The reason for the differential restrictions on sequence remains unexplained. Here, we show that the evolution of...

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Identifiers

PMID: 19815527
DOI: 10.1073/pnas.0906390106
PMCID: PMC2764890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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