Article

The SARS-CoV-2 protein NSP2 impairs the microRNA-induced silencing capacity of human cells

2022-01-26

Abstract excerpt

The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19. Given the absence of effective treatments against SARS-CoV-2, there is an urgent need for a molecular understanding of how the virus influences the machineries of the host cell. The SARS-CoV-2 generates 16 Non-Structural Proteins (NSPs) through proteolytic cleavage of a large precursor protein. In the present study, we focused our attenti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67186369-6113-5376-a194-f07f661ecc16
DOI: 10.1101/2022.01.25.477753

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SARS-CoV-2 protein NSP2 impairs the microRNA-induced silencing capacity of human cellsDOI 10.1101/2022.01.25.477753Read

SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repressionSemantic proximity Read

The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infectionsSemantic proximity Read

SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammationSemantic proximity Read

SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditionsSemantic proximity Read

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptomeSemantic proximity Read

Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactionsSemantic proximity Read

Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNASemantic proximity Read

Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactionsSemantic proximity Read

SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replicationSemantic proximity Read

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translationSemantic proximity Read

SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genesSemantic proximity Read

Structure of the SARS-CoV-2 Nsp1/5′-Untranslated Region Complex and Implications for Potential Therapeutic Targets, a Vaccine, and VirulenceSemantic proximity Read