Article

SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

2023-01-03

Abstract excerpt

microRNAs (miRNAs) inhibit mRNA translation initiation by recruiting the GIGYF2/4EHP translation repressor complex to the mRNA 5’ cap structure. Viruses utilise miRNAs to impair the host antiviral immune system and facilitate viral infection by expressing their own miRNAs or co-opting cellular miRNAs. We recently reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encoded non-structural...

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Literature Corpus work: 9c444a82-8a5b-560f-a089-8cc015f0878c
DOI: 10.1101/2023.01.01.522328

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