Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

11 Mar 2022

Abstract excerpt

Viral infection involves complex set of events orchestrated by multiple viral proteins. To identify functions of SARS-CoV-2 proteins, we performed transcriptomic analyses of cells expressing individual viral proteins. Expression of Nsp14, a protein involved in viral RNA replication, provoked a dramatic remodeling of the transcriptome that strongly resembled that observed following SARS-CoV-2 infection. Moreover,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35293857
DOI: 10.7554/elife.71945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptomePMID 35293857Read ↗

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 proteinSemantic proximity Read ↗

Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signalingSemantic proximity Read ↗

Functional Landscape of SARS-CoV-2 Cellular RestrictionSemantic proximity Read ↗

Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity Read ↗

Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactionsSemantic proximity Read ↗

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infectionSemantic proximity Read ↗

Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.Semantic proximity Read ↗

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in <i>Betacoronavirus</i> replicationSemantic proximity Read ↗

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesisSemantic proximity Read ↗

SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammationSemantic proximity Read ↗

Functional Landscape of SARS-CoV-2 Cellular RestrictionSemantic proximity Read ↗

Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.