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Article

The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections

22 Feb 2024

Abstract excerpt

Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral infections. It plays a pivotal role in hijacking and rendering the host gene expression under the service of the virus. With a focus on SARS-CoV-2, this review presents how Nsp1 selectively inhibits host protein synthesis and induces mRNA degradation of host but not viral mRNAs and blocks nuclear mRNA export. The clinical...

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Identifiers

PMID: 38385526
DOI: 10.1042/bst20231119

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