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Article

SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

30 Mar 2023

Abstract excerpt

When viruses like SARS-CoV-2 infect cells, they reprogram the repertoire of cellular and viral transcripts that are being translated to optimize their strategy of replication, often targeting host translation initiation factors, particularly eIF4F complex consisting of eIF4E, eIF4G and eIF4A. A proteomic analysis of SARS-CoV-2/human proteins interaction revealed viral Nsp2 and initiation factor eIF4E2, but a role...

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PMID: 36998012
DOI: 10.1186/s12985-023-02021-2

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