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Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients

14 Jan 2020

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a significant socioeconomic burden. The pathogenesis of MS involves both genetic susceptibility and exposure to distinct environmental risk factors. The gene x environment...

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PMID: 31937331
DOI: 10.1186/s12974-019-1667-1

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