Article

Rationally designed split Lettuce aptamer based on large scale mutational analysis

2026-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Split aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is frequently limited by the lack of robust design rules for selecting effective split sites. Existing approaches largely rely on heuristic, structure-based assumptions that are poorly validated and often yield suboptimal signal. Herein, we introduce a sy...

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Literature Corpus work: 66ef6b8c-7027-52db-9025-a5f768e65cc2
DOI: 10.64898/2026.07.10.737091

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