Article
High-Throughput On-Chip Screening Enables Rapid Adaptation of DNA Aptamers to SARS-CoV-2 Evolution.
ACS nano - 1 Sept 2026
He Yujie, Yang Zhenglin, Kuo Yu-An, Wu Yuting, Fonseca-Albert Diego, Le Kyle K, Guo Jeffrey, Wang Yanxing, Nguyen Anh-Thu, Chen Yuan-I, Kim Sohyun, Chen Wei-Ru, Seifi Saeed, Hong Soonwoo, Nguyen Trung Duc, Chen Yinong, Ren Pengyu, Lu Yi, Yeh Hsin-Chih
Abstract excerpt
Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10-12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral evolution, rendering many neutralizing antibodies ineffective. Here, we...
Read the complete abstract on PubMedTopics
- Aptamers, Nucleotide
- SARS-CoV-2
- High-Throughput Screening Assays
- Spike Glycoprotein, Coronavirus
- Humans
- Mutation
- COVID-19