Article

Programmable Fluorescent Aptamer-Based RNA Switches for Rapid Identification of Point Mutations

2025-03-10

Abstract excerpt

<h4>ABSTRACT</h4> The ability to detect single-nucleotide polymorphisms (SNPs) is critical for identifying genetic disorders, assessing pathogen drug resistance, and preventing infection transmission. Achieving a delicate balance across sequence-specific recognition, RNA structural stability, and functional efficacy based on SNP-induced changes in RNA structure is crucial to precise genotyping using RNA-based prob...

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Literature Corpus work: 9c9d8e26-3711-5d67-8d46-1515eea1ac6b
DOI: 10.1101/2025.03.07.25323576

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